The call: The oral matchup, and against the hype: oral semaglutide out-does orforglipron on both efficacy and tolerability, so it takes the class-leading grade. Orforglipron's real case is convenience: no fasting rule, no cold chain, and small-molecule manufacturing that scales. If you want the most loss from a pill, oral semaglutide; if access and living with it decide, orforglipron is the one you will actually keep taking.