Oral division
Oral semaglutide 25 mg
AClass-leading
Novo Nordisk · approved
vs
Injectable division
Retatrutide
Class-leadingA
Eli Lilly · certified
11%
Efficacy
10 pts more · 21%
Clean (+1) · gentler
Tolerability
Notable (+6.4)
Oral pill
Route
Subcutaneous injection
Must take fasting: empty stomach, limited water, wait before eating
Food / water rule
None
Room temperature
Storage
Refrigerated
The trade: Different divisions, so this is the trade, not a verdict. Retatrutide loses about 10 more points of body weight. Oral semaglutide 25 mg adds convenience: a daily pill instead of a once weekly injection, no cold chain. Oral semaglutide 25 mg has its own catch: it must be taken fasting. If maximum loss matters most and an injection is acceptable, Retatrutide; if avoiding the needle matters more, Oral semaglutide 25 mg.
Standalone, this page carries its own key: Efficacy = % body weight lost vs placebo, on the conservative estimand that counts everyone. Tolerability = AE-discontinuation over placebo (Mild 1 to 5 · Notable 5 to 10 · Heavy over 10 points). Different divisions, so efficacy is shown as raw magnitude, not a verdict. The side marked leads or gentler wins that axis.
Oral semaglutide 25 mg verdict · Retatrutide verdict · Is the pill as good as the shot? · How this is scored