The board / Oral semaglutide 25 mg vs Semaglutide 2.4 mg
Oral division

Oral semaglutide 25 mg

AClass-leading
Novo Nordisk · approved
vs
Injectable division

Semaglutide 2.4 mg (Wegovy)

CompetitiveB
Novo Nordisk · approved
11%
Efficacy
1 pt more · 12%
Clean (+1) · gentler
Tolerability
Mild (+3.9)
Oral pill
Route
Subcutaneous injection
Must take fasting: empty stomach, limited water, wait before eating
Food / water rule
None
Room temperature
Storage
Refrigerated (room temperature up to 28 days)
The trade: Same molecule, two routes. Both are semaglutide: the 2.4 mg weekly injection (Wegovy), or the approved 25 mg daily pill. On treatment-policy loss the injection is about a point ahead (12% vs 11%), but the pill is the gentler of the two and skips the needle and cold chain; its price is the daily fasting routine, taken on an empty stomach with limited water and a wait before eating. A higher 50 mg pill, not approved, closes that gap, but the board scores the approved 25 mg. So this stays close to a delivery choice: the injection for the last point of loss, the pill to dodge the needle if the morning routine is one you will keep.
Standalone, this page carries its own key: Efficacy = % body weight lost vs placebo, on the conservative estimand that counts everyone. Tolerability = AE-discontinuation over placebo (Mild 1 to 5 · Notable 5 to 10 · Heavy over 10 points). Different divisions, so efficacy is shown as raw magnitude, not a verdict. The side marked leads or gentler wins that axis.

Oral semaglutide 25 mg verdict · Semaglutide 2.4 mg verdict · Is the pill as good as the shot? · How this is scored